Current Issue : July-September Volume : 2011 Issue Number : 3 Articles : 5 Articles
Different aspects of transition metal chemistry have been widely studied over the past decades because of their interesting structures, chemical reactivity and properties. Historically, Lewis acidic metal coordination complexes have played a pivotal and defining role in the broad field of molecular recognition and more specifically in the sensing and sequestration of biologically relevant anionic species. More recently, with the expanding interest in chemical biology, there has been resurgence in the use of coordination complexes, specifically, through their application as medicinal therapeutics and chemo/biosensors. From the disruption of oncogenic protein–protein interactions to the fluorescent sensing of PTP1B phosphatase enzyme activity, the powerful binding potency of coordination complexes has been harnessed to great effect. Herein, we will review the recent advances in the application of coordination complexes in medicinal and chemo/biosensory roles over the last decade. In particular, this review will focus on Cu (II) and Zn (II) coordination complexes....
The Niflumic acid have indicated the gastrointestinal side effects due to the acidic moiety of the Niflumic acid. Therefore an attempt has been made to prepare the mutual Prodrug using Propyphenazone as a carrier moiety via ester linkage.The synthesized prodrug were characterised by melting point, UV,IR and NMR spectroscopy....
The synthesis and biological importance of some new seriesof benzofuran derivatives were reported. Condensation reaction of 2-hydroxy–benzonirile with ethylchloroacetate in the presence of dry potassium carbonate in dry acetone affords ethyl 3-amino-1-benzofuran-2-carboxylate 2. The reaction of compound 2 on treatment with hydrazine hydrate afforded compound 3 with excellent yield. The synthesis of 1,3,4-oxadiazol derivatives 4a-e have been achieved by direct cyclisation of 3-amino-1-benzofuran-2-carbohydrazide(3) with various fatty acids in the presence of POCl3. The structures of all newly synthesized compounds were confirmed by IR, 1H NMR, and Mass spectral data. Newly synthesized compounds were screened analgesic and antimicrobial activity. Compounds 4a and 4b proved to be efficient in their action comparable to standard drug acetyl salicylic acid. This investigation revealed that the synthesized compounds are potential anti bacterial and antinociceptive agents....
A series of new Coumarin - derived Schiff’s base derivatives were synthesized, characterized and screened for their in vitro anti bacterial activity against range of Gram - positive and Gram - negative as well as for their anti fungal activity against a clinical isolate of Candida albicans. The synthesis of Schiff’s bases was carried out by reaction of series of aromatic aldehydes with 8-amino-4-methyl-2h-chromen-2-one (I). Later compound was obtained by the reaction of β – keto ester with 2 – amino phenol by using well known Pechmann condensation using stannous chloride dihydrate as catalyst. All the compounds were characterized with the help of IR and NMR spectroscopy. Compound 2b possess highest anti bacterial activity. While compound 2e possesses highest anti fungal activity....
In the present research work novel series of heterocyclic like 2, 5, 6 substituted triazolo-thiadiazole with metal-ligands complexes (Zinc and Copper) were synthesized. The heterocyclic incorporated with isoniazide which then evaluated for antimicrobial. The method of synthesis of some triazolo-thiadiazoles involves the reaction between Thiosemicarbazide (I) and substituted aromatic acids undergo cyclization to give 2-amino-5-aryl-1, 3, 4-thiadiazole (II). Again its Schiff base 5-phenyl-N-[(1Z)-phenylmethylene]-1,3,4-thiadiazol-2-amine (III) reaction is done with aromatic aldehydes by alkyl-iminodeoxobisubstitution. Then 2, 5, 6 substituted Triazolo-thiadiazole (IV) derivatives are prepared by using and Isoniazide Anhydrous FeCl3. Various derivatives were prepared with different aromatic acids (salicylic acid, Nicotinic acid and Para amino benzoic acid) and aromatic aldehydes (4-OH-Benzaldehyde and Furfural). And then in the last step the metal complexes (V) were prepared with CuCl2 and ZnCl2 reflux in ethanol with drop wise addition of alcoholic ammonia to raise the pH of mixture to 6.5. The synthesized compounds were characterized by IR, Mass, 1H-NMR, UV-visible spectrum and Elemental Analysis. After synthesis the chemical compounds were screened for their biological activity against gram Negative and gram positive bacteria and also fungi using agar-well diffusion method. Compounds (1A1, 1B1, 2B1, 3B1) were found to be the most effective compound against fungal microorganisms. Compounds (1A2, 1B2, 2A2, 3B2) were found to be more effective against bacterial microorganisms. All the compounds were found to be nearly Shown promising antimicrobial activities....
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